Laboratoire de Microbiologie Fondamentale et Pathogénicité

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Intermediate metabolism of trypanosomes

 

Responsable :

Frédéric BRINGAUD

 

Membres de l'équipe :

 

Site de l'équipe : Cliquer ici

 

Publications :

Allmann S, Bringaud F. Glycosomes: A comprehensive view of their metabolic roles in T. brucei.Int J Biochem Cell Biol. 2017 Apr;85:85-90

Mantilla BS, Marchese L, Casas-Sánchez A, Dyer NA, Ejeh N, Biran M, Bringaud F, Lehane MJ, Acosta-Serrano A, Silber AM. Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.PLoS Pathog. 2017 Jan;13(1):e1006158

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK. Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.Protein Eng Des Sel. 2017 Mar 1;30(3):225-233

Surve SV, Jensen BC, Heestand M, Mazet M, Smith TK, Bringaud F, Parsons M, Schnaufer A. NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms.Mol Biochem Parasitol. 2017 Jan;211:57-61

Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepción JL, Hashimoto T, Embley TM, Nara T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.Proc Biol Sci. 2016 May 11;283(1830)

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK. The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.Proteins. 2016 Aug;84(8):1075-96

Štáfková J, Mach J, Biran M, Verner Z, Bringaud F, Tachezy J. Mitochondrial pyruvate carrier in Trypanosoma brucei.Mol Microbiol. 2016 May;100(3):442-56

Jackson AP, Otto TD, Aslett M, Armstrong SD, Bringaud F, Schlacht A, Hartley C, Sanders M, Wastling JM, Dacks JB, Acosta-Serrano A, Field MC, Ginger ML, Berriman M. Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism.Curr Biol. 2016 Jan 25;26(2):161-172

Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Weidt SK, Burgess KE, Breitling R, Watson DG, Bringaud F, Barrett MP. Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.PLoS Pathog. 2015 Mar;11(3):e1004689

Bringaud F, Biran M, Millerioux Y, Wargnies M, Allmann S, Mazet M. Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways.Mol Microbiol. 2015 Jun;96(5):917-26

Allmann S, Mazet M, Ziebart N, Bouyssou G, Fouillen L, Dupuy JW, Bonneu M, Moreau P, Bringaud F, Boshart M. Triacylglycerol Storage in Lipid Droplets in Procyclic Trypanosoma brucei.PLoS One. 2014;9(12):e114628

Bringaud F, Rogers M, Ghedin E. Identification and analysis of ingi-related retroposons in the trypanosomatid genomes.Methods Mol Biol. 2015;1201:109-22

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44

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