Minimal metabolism allowing Candida yeast to be pathogenic to humans
Yeast-macrophage interaction, lipid metabolism, neoglucogenesis.
Intra-macrophagic surviving yeasts (blue cells)
- Whole proteome analysis of intra-macrophagic surviving yeasts by mass spectrometry
- Identification of proteins and metabolic pathways up- and down expressed in our annotated genome database
- Highlighting the major role of yeast lipid metabolism for intra-macrophagic survival
- Identification of several fatty acids catabolism pathways in Candida, involving or not involving Fox2p, the main enzyme of fatty acid beta-oxidation in yeasts
- Demonstration for the first time in ascomycetous yeast that Fox2p can localize both in peroxisomes and mitochondria.
- The movie was shot in the BIC studios at Bordeaux University
- Executive producer: El-Kirat-Chatel Sofiane
- Associate producer: Dementhon Karine
- Senior Direction production: Noël Thierry
Starring C. lusitaniae and macrophages
C. lusitaniae, alias the "bad" cell and Macrophages, alias the "good" cells respectively
Immunoelectron microscopy showing Fox2p localizing both in peroxysomes (P) and mitochondria (M)