Vincent Parissi’s Group

« Mobility of pathogenic genomes and chromatin dynamics » MoBileVIR

Key words

Viruses, Retroviruses, Integration, Integrases, DNA mobility, Chromatin, DNA repair

Objectives:

Identify molecular exchanges between pathogenic mobile elements (viral and pseudoviral) and the host.

Scientific topics:

DNA and chromatin, or pseudocromatin, structures regulate numerous biological and pathogenic mechanisms as bacterial integrons mobilisation or retroviral integration. These processes constitute therapeutic target and attractive tools for gene transfer/therapy. Our team aims to understand these mechanisms in different models of mobile elements (viral infections, procaryotic, eukaryotic and viral integration/transposition) using complementary biophysics, biochemistry, structural/cellular biology and pharmacology approaches (Fig 1).

Cellular approaches