Publications

Here, the full list of UMR-5234 publications.


2020

Daussy CF, Wodrich H. "Repair Me if You Can": Membrane Damage, Response, and Control from the Viral Perspective. Cells. 2020 9, . PubMed PMID:32906744

Zhang W, Mese K, Schellhorn S, Bahlmann N, Mach N, Bunz O, Dhingra A, Hage E, Lafon ME, Wodrich H, Heim A, Ehrhardt A. High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75. Int J Mol Sci. 2020 21, . PubMed PMID:32887347

Frénal K, Krishnan A, Soldati-Favre D. The Actomyosin Systems in Apicomplexa. Adv Exp Med Biol. 2020 1239, 331-354. PubMed PMID:32451865

Messore A, Corona A, Madia VN, Saccoliti F, Tudino V, De Leo A, Scipione L, De Vita D, Amendola G, Di Maro S, Novellino E, Cosconati S, Métifiot M, Andreola ML, Valenti P, Esposito F, Grandi N, Tramontano E, Costi R, Di Santo R. Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase. ACS Med Chem Lett. 2020 11, 798-805. PubMed PMID:32435387

Dogga SK, Frénal K. Two palmitoyl acyltransferases involved sequentially in the biogenesis of the inner membrane complex of Toxoplasma gondii. Cell Microbiol. 2020 22, e13212. PubMed PMID:32329212

Mhaya A, Bégu D, Tounsi S, Arpin C. MgrB Inactivation Is Responsible for Acquired Resistance to Colistin in Enterobacter hormaechei subsp. steigerwaltii. Antimicrob Agents Chemother. 2020 64, . PubMed PMID:32253218

Mhaya A, Trabelsi R, M'Zali F, Bégu D, Tounsi S, Gdoura R, Arpin C. First description of NDM-1-positive Klebsiella pneumoniae in the Tunisian community. J Glob Antimicrob Resist. 2020 21, 49-50. PubMed PMID:32169682

Carlon-Andres I, Lagadec F, Pied N, Rayne F, Lafon ME, Kehlenbach RH, Wodrich H. Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import. J Virol. 2020 94, . PubMed PMID:32161167

Kauss T, Arpin C, Bientz L, Vinh Nguyen P, Vialet B, Benizri S, Barthélémy P. Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance. Sci Rep. 2020 10, 1054. PubMed PMID:31974472

Vidilaseris K, Landrein N, Pivovarova Y, Lesigang J, Aeksiri N, Robinson DR, Bonhivers M, Dong G. Crystal structure of the N-terminal domain of the trypanosome flagellar protein BILBO1 reveals a ubiquitin fold with a long structured loop for protein binding. J Biol Chem. 2020 295, 1489-1499. PubMed PMID:31882537

Genoveso MJ, Hisaoka M, Komatsu T, Wodrich H, Nagata K, Okuwaki M. Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1. FEBS J. 2020 287, 205-217. PubMed PMID:31365788

2019

Pied N, Wodrich H. Imaging the adenovirus infection cycle. FEBS Lett. 2019 593, 3419-3448. PubMed PMID:31758703

Lorès P, Dacheux D, Kherraf ZE, Nsota Mbango JF, Coutton C, Stouvenel L, Ialy-Radio C, Amiri-Yekta A, Whitfield M, Schmitt A, Cazin C, Givelet M, Ferreux L, Fourati Ben Mustapha S, Halouani L, Marrakchi O, Daneshipour A, El Khouri E, Do Cruzeiro M, Favier M, Guillonneau F, Chaudhry M, Sakheli Z, Wolf JP, Patrat C, Gacon G, Savinov SN, Hosseini SH, Robinson DR, Zouari R, Ziyyat A, Arnoult C, Dulioust E, Bonhivers M, Ray PF, Touré A. Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility. Am J Hum Genet. 2019 105, 1148-1167. PubMed PMID:31735292

Aknin C, Smith EA, Marchand C, Andreola ML, Pommier Y, Metifiot M. Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening. Molecules. 2019 24, . PubMed PMID:31614773

Lee GE, Mauro E, Parissi V, Shin CG, Lesbats P. Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses. Viruses. 2019 11, . PubMed PMID:31443391

Prevel R, Boyer A, M'Zali F, Cockenpot T, Lasheras A, Dubois V, Gruson D. Extended spectrum beta-lactamase producing Enterobacterales faecal carriage in a medical intensive care unit: low rates of cross-transmission and infection. Antimicrob Resist Infect Control. 2019 8, 112. PubMed PMID:31333839

Szöőr B, Simon DV, Rojas F, Young J, Robinson DR, Krüger T, Engstler M, Matthews KR. Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation. mBio. 2019 10, . PubMed PMID:31289175

Su X, Rak M, Tetaud E, Godard F, Sardin E, Bouhier M, Gombeau K, Caetano-Anollés D, Salin B, Chen H, di Rago JP, Tribouillard-Tanvier D. Deregulating mitochondrial metabolite and ion transport has beneficial effects in yeast and human cellular models for NARP syndrome. Hum Mol Genet. 2019 28, 3792-3804. PubMed PMID:31276579

Dauchy FA, Contin-Bordes C, Nzoumbou-Boko R, Bonhivers M, Landrein N, Robinson DR, Rambert J, Courtois P, Daulouède S, Vincendeau P. Trypanosoma brucei gambiense excreted/secreted factors impair lipopolysaccharide-induced maturation and activation of human monocyte-derived dendritic cells. Parasite Immunol. 2019 41, e12632. PubMed PMID:31099071

Corvaglia V, Carbajo D, Prabhakaran P, Ziach K, Mandal PK, Santos VD, Legeay C, Vogel R, Parissi V, Pourquier P, Huc I. Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins. Nucleic Acids Res. 2019 47, 5511-5521. PubMed PMID:31073604

Alves BM, Siqueira JD, Prellwitz IM, Botelho OM, Da Hora VP, Sanabani S, Recordon-Pinson P, Fleury H, Soares EA, Soares MA. Estimating HIV-1 Genetic Diversity in Brazil Through Next-Generation Sequencing. Front Microbiol. 2019 10, 749. PubMed PMID:31024510

Nkongolo S, Nußbaum L, Lempp FA, Wodrich H, Urban S, Ni Y. The retinoic acid receptor (RAR) α-specific agonist Am80 (tamibarotene) and other RAR agonists potently inhibit hepatitis B virus transcription from cccDNA. Antiviral Res. 2019 168, 146-155. PubMed PMID:31018112

Basmaciyan L, Robinson DR, Azas N, Casanova M. (De)glutamylation and cell death in Leishmania parasites. PLoS Negl Trop Dis. 2019 13, e0007264. PubMed PMID:31017892

Courtois P, Nabos P, Nzoumbou-Boko R, Reix CE, Dauchy FA, Daulouede S, Bringaud F, Robinson DR, Vincendeau P. Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns). J Vis Exp. 2019 , . PubMed PMID:31009012

Richetta C, Thierry S, Thierry E, Lesbats P, Lapaillerie D, Munir S, Subra F, Leh H, Deprez E, Parissi V, Delelis O. Two-long terminal repeat (LTR) DNA circles are a substrate for HIV-1 integrase. J Biol Chem. 2019 294, 8286-8295. PubMed PMID:30971426

Laurian R, Dementhon K, Doumèche B, Soulard A, Noel T, Lemaire M, Cotton P. Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans. Front Microbiol. 2019 10, 327. PubMed PMID:30858840

Tumiotto C, Alves BM, Recordon-Pinson P, Jourdain M, Bellecave P, Guidicelli GL, Visentin J, Bonnet F, Hessamfar M, Neau D, Sanchez J, Brander C, Sajadi M, Eyzaguirre L, Soares EA, Routy JP, Soares MA, Fleury H. Provir/Latitude 45 study: A step towards a multi-epitopic CTL vaccine designed on archived HIV-1 DNA and according to dominant HLA I alleles. PLoS One. 2019 14, e0212347. PubMed PMID:30811489

Mauro E, Lesbats P, Lapaillerie D, Chaignepain S, Maillot B, Oladosu O, Robert X, Fiorini F, Kieffer B, Bouaziz S, Gouet P, Ruff M, Parissi V. Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase. Nucleic Acids Res. 2019 47, 3607-3618. PubMed PMID:30767014

Coutton C, Martinez G, Kherraf ZE, Amiri-Yekta A, Boguenet M, Saut A, He X, Zhang F, Cristou-Kent M, Escoffier J, Bidart M, Satre V, Conne B, Fourati Ben Mustapha S, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Pernet-Gallay K, Bonhivers M, Hennebicq S, Rives N, Dulioust E, Touré A, Gourabi H, Cao Y, Zouari R, Hosseini SH, Nef S, Thierry-Mieg N, Arnoult C, Ray PF. Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice. Am J Hum Genet. 2019 104, 331-340. PubMed PMID:30686508

Florini F, Naguleswaran A, Gharib WH, Bringaud F, Roditi I. Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei. Nucleic Acids Res. 2019 47, 1725-1739. PubMed PMID:30544263

Accoceberry I, Couzigou C, Fitton-Ouhabi V, Biteau N, Noël T. Challenging SNP impact on caspofungin resistance by full-length FKS1 allele replacement in Candida lusitaniae. J Antimicrob Chemother. 2019 74, 618-624. PubMed PMID:30517635

2018

Wargnies M, Bertiaux E, Cahoreau E, Ziebart N, Crouzols A, Morand P, Biran M, Allmann S, Hubert J, Villafraz O, Millerioux Y, Plazolles N, Asencio C, Rivière L, Rotureau B, Boshart M, Portais JC, Bringaud F. Gluconeogenesis is essential for trypanosome development in the tsetse fly vector. PLoS Pathog. 2018 14, e1007502. PubMed PMID:30557412

Lesbats P, Parissi V. Retroviral integration site selection: a running Gag?. Microb Cell. 2018 5, 569-571. PubMed PMID:30533422

Pineda E, Thonnus M, Mazet M, Mourier A, Cahoreau E, Kulyk H, Dupuy JW, Biran M, Masante C, Allmann S, Rivière L, Rotureau B, Portais JC, Bringaud F. Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions. PLoS Pathog. 2018 14, e1007412. PubMed PMID:30383867

Cirri E, Brier S, Assal R, Canul-Tec JC, Chamot-Rooke J, Reyes N. Consensus designs and thermal stability determinants of a human glutamate transporter. Elife. 2018 7, . PubMed PMID:30334738

Poirel L, Ortiz De La Rosa JM, Kieffer N, Dubois V, Jayol A, Nordmann P. Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 63, . PubMed PMID:30323045

Martinez G, Kherraf ZE, Zouari R, Fourati Ben Mustapha S, Saut A, Pernet-Gallay K, Bertrand A, Bidart M, Hograindleur JP, Amiri-Yekta A, Kharouf M, Karaouzène T, Thierry-Mieg N, Dacheux-Deschamps D, Satre V, Bonhivers M, Touré A, Arnoult C, Ray PF, Coutton C. Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella. Hum Reprod. 2018 33, 1973-1984. PubMed PMID:30137358

Kherraf ZE, Amiri-Yekta A, Dacheux D, Karaouzène T, Coutton C, Christou-Kent M, Martinez G, Landrein N, Le Tanno P, Fourati Ben Mustapha S, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Pernet-Gallay K, Gourabi H, Robinson DR, Crouzy S, Blum M, Thierry-Mieg N, Touré A, Zouari R, Arnoult C, Bonhivers M, Ray PF. A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility. Am J Hum Genet. 2018 103, 400-412. PubMed PMID:30122540

Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR Jr. HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence. Molecules. 2018 23, . PubMed PMID:30049955

Robert-Gangneux F, Meroni V, Dupont D, Botterel F, Garcia JMA, Brenier-Pinchart MP, Accoceberry I, Akan H, Abbate I, Boggian K, Bruschi F, Carratalà J, David M, Drgona L, Djurković-Djaković O, Farinas MC, Genco F, Gkrania-Klotsas E, Groll AH, Guy E, Hirzel C, Khanna N, Kurt Ö, Junie LM, Lazzarotto T, Len O, Mueller NJ, Munoz P, Pana ZD, Roilides E, Stajner T, van Delden C, Villena I, Pelloux H, Manuel O. Toxoplasmosis in Transplant Recipients, Europe, 2010-2014. Emerg Infect Dis. 2018 24, 1497-1504. PubMed PMID:30014843

Komatsu T, Quentin-Froignant C, Carlon-Andres I, Lagadec F, Rayne F, Ragues J, Kehlenbach RH, Zhang W, Ehrhardt A, Bystricky K, Morin R, Lagarde JM, Gallardo F, Wodrich H. In Vivo Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication. J Virol. 2018 92, . PubMed PMID:29997215

Fabre A, Oleastro M, Nunes A, Santos A, Sifré E, Ducournau A, Bénéjat L, Buissonnière A, Floch P, Mégraud F, Dubois V, Lehours P. Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants. J Clin Microbiol. 2018 56, . PubMed PMID:29976591

Recordon-Pinson P, Alves BM, Tumiotto C, Bellecave P, Bonnet F, Neau D, Soares EA, Soares MA, Fleury H. A New HIV-1 Circulating Recombinant Form (CRF98_cpx) Between CRF06_cpx and Subtype B Identified in Southwestern France. AIDS Res Hum Retroviruses. 2018 34, 1005-1009. PubMed PMID:29947242

Jayol A, Poirel L, André C, Dubois V, Nordmann P. Detection of colistin-resistant Gram-negative rods by using the SuperPolymyxin medium. Diagn Microbiol Infect Dis. 2018 92, 95-101. PubMed PMID:29885757

Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F. De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions. PLoS Pathog. 2018 14, e1007116. PubMed PMID:29813135

Jaubert C, Bedrat A, Bartolucci L, Di Primo C, Ventura M, Mergny JL, Amrane S, Andreola ML. RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand. Sci Rep. 2018 8, 8120. PubMed PMID:29802381

Marchese L, Nascimento JF, Damasceno FS, Bringaud F, Michels PAM, Silber AM. The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids. Pathogens. 2018 7, . PubMed PMID:29614775

Ziach K, Chollet C, Parissi V, Prabhakaran P, Marchivie M, Corvaglia V, Bose PP, Laxmi-Reddy K, Godde F, Schmitter JM, Chaignepain S, Pourquier P, Huc I. Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA. Nat Chem. 2018 10, 511-518. PubMed PMID:29610464

Dong FN, Amiri-Yekta A, Martinez G, Saut A, Tek J, Stouvenel L, Lorès P, Karaouzène T, Thierry-Mieg N, Satre V, Brouillet S, Daneshipour A, Hosseini SH, Bonhivers M, Gourabi H, Dulioust E, Arnoult C, Touré A, Ray PF, Zhao H, Coutton C. Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse. Am J Hum Genet. 2018 102, 636-648. PubMed PMID:29606301

de Seynes C, de Barbeyrac B, Dutronc H, Ribes C, Crémer P, Dubois V, Fabre T, Dupon M, Dauchy FA. Contribution of a multiplex serological test for the preoperative diagnosis of prosthetic joint infection: a prospective study. Infect Dis (Lond). 2018 50, 609-615. PubMed PMID:29564939

Kovářová J, Pountain AW, Wildridge D, Weidt S, Bringaud F, Burchmore RJS, Achcar F, Barrett MP. Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. PLoS Pathog. 2018 14, e1006953. PubMed PMID:29554142

2017

Benleulmi MS, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, Lesbats P, Chaignepain S, Henriquez DR, Calmels C, Oladosu O, Thierry E, Leon O, Lavigne M, Andreola ML, Delelis O, Ivics Z, Ruff M, Gouet P, Parissi V. Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails. Retrovirology. 2017 14, 54. PubMed PMID:29179726

Albisetti A, Florimond C, Landrein N, Vidilaseris K, Eggenspieler M, Lesigang J, Dong G, Robinson DR, Bonhivers M. Interaction between the flagellar pocket collar and the hook complex via a novel microtubule-binding protein in Trypanosoma brucei. PLoS Pathog. 2017 13, e1006710. PubMed PMID:29091964

Garcia-Silva MR, Sollelis L, MacPherson CR, Stanojcic S, Kuk N, Crobu L, Bringaud F, Bastien P, Pagès M, Scherf A, Sterkers Y. Identification of the centromeres of Leishmania major: revealing the hidden pieces. EMBO Rep. 2017 18, 1968-1977. PubMed PMID:28935715

Tumiotto C, Riviere L, Bellecave P, Recordon-Pinson P, Vilain-Parce A, Guidicelli GL, Fleury H, Provir/Latitude 45 collaborating group. Sanger and Next-Generation Sequencing data for characterization of CTL epitopes in archived HIV-1 proviral DNA. PLoS One. 2017 12, e0185211. PubMed PMID:28934310

Rayne F, Wittkop L, Bader C, Kassab S, Tumiotto C, Berciaud S, Wodrich H, Lafon ME, Typadeno Study Members. Rapid Adenovirus typing method for species identification. J Virol Methods. 2017 249, 156-160. PubMed PMID:28918074

Quilès F, Accoceberry I, Couzigou C, Francius G, Noël T, El-Kirat-Chatel S. AFM combined to ATR-FTIR reveals Candida cell wall changes under caspofungin treatment. Nanoscale. 2017 9, 13731-13738. PubMed PMID:28884772

Jayol A, Nordmann P, Brink A, Villegas MV, Dubois V, Poirel L. High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2017 61, . PubMed PMID:28874377

Dannaoui E, Gabriel F, Gaboyard M, Lagardere G, Audebert L, Quesne G, Godichaud S, Verweij PE, Accoceberry I, Bougnoux ME. Molecular Diagnosis of Invasive Aspergillosis and Detection of Azole Resistance by a Newly Commercialized PCR Kit. J Clin Microbiol. 2017 55, 3210-3218. PubMed PMID:28814586

Durrens P, Klopp C, Biteau N, Fitton-Ouhabi V, Dementhon K, Accoceberry I, Sherman DJ, Noël T. Genome Sequence of the Yeast Clavispora lusitaniae Type Strain CBS 6936. Genome Announc. 2017 5, . PubMed PMID:28774979

Matysiak J, Lesbats P, Mauro E, Lapaillerie D, Dupuy JW, Lopez AP, Benleulmi MS, Calmels C, Andreola ML, Ruff M, Llano M, Delelis O, Lavigne M, Parissi V. Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration. Retrovirology. 2017 14, 39. PubMed PMID:28754126

Zhao XZ, Smith SJ, Maskell DP, Métifiot M, Pye VE, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR Jr. Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J Med Chem. 2017 60, 7315-7332. PubMed PMID:28737946

Jayol A, Nordmann P, André C, Dubois V, Poirel L. Increased colistin resistance upon acquisition of the plasmid-mediated mcr-1 gene in Escherichia coli isolates with chromosomally encoded reduced susceptibility to polymyxins. Int J Antimicrob Agents. 2017 50, 503-504. PubMed PMID:28729123

Sbicca L, González AL, Gresika A, Di Giorgio A, Closa JT, Tejedor RE, Andréola ML, Azoulay S, Patino N. Exploring the impact of the side-chain length on peptide/RNA binding events. Phys Chem Chem Phys. 2017 19, 18452-18460. PubMed PMID:28681892

Montespan C, Wiethoff CM, Wodrich H. A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy. J Virol. 2017 91, . PubMed PMID:28659475

Normand AC, Becker P, Gabriel F, Cassagne C, Accoceberry I, Gari-Toussaint M, Hasseine L, De Geyter D, Pierard D, Surmont I, Djenad F, Donnadieu JL, Piarroux M, Ranque S, Hendrickx M, Piarroux R. Validation of a New Web Application for Identification of Fungi by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. J Clin Microbiol. 2017 55, 2661-2670. PubMed PMID:28637907

Smith TK, Bringaud F, Nolan DP, Figueiredo LM. Metabolic reprogramming during the Trypanosoma brucei life cycle. F1000Res. 2017 6, . PubMed PMID:28620452

Saly M, Jayol A, Poirel L, Megraud F, Nordmann P, Dubois V. Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016. J Med Microbiol. 2017 66, 842-843. PubMed PMID:28598315

Jayol A, Saly M, Nordmann P, Ménard A, Poirel L, Dubois V. Hafnia, an enterobacterial genus naturally resistant to colistin revealed by three susceptibility testing methods. J Antimicrob Chemother. 2017 72, 2507-2511. PubMed PMID:28586429

Calmels C, Ventura M, Aknin C, Métifiot M, Andreola ML. De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain. Sci Rep. 2017 7, 2697. PubMed PMID:28577343

Jaspart A, Calmels C, Cosnefroy O, Bellecave P, Pinson P, Claverol S, Guyonnet-Dupérat V, Dartigues B, Benleulmi MS, Mauro E, Gretteau PA, Parissi V, Métifiot M, Andreola ML. GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration. Sci Rep. 2017 7, 2283. PubMed PMID:28536474

2016

Navarro-Arias MJ, Defosse TA, Dementhon K, Csonka K, Mellado-Mojica E, Dias Valério A, González-Hernández RJ, Courdavault V, Clastre M, Hernández NV, Pérez-García LA, Singh DK, Vizler C, Gácser A, Almeida RS, Noël T, López MG, Papon N, Mora-Montes HM. Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence. Front Microbiol. 2016 7, 1951. PubMed PMID:27994582

Maamar E, Ferjani S, Jendoubi A, Hammami S, Hamzaoui Z, Mayonnove-Coulange L, Saidani M, Kammoun A, Rehaiem A, Ghedira S, Houissa M, Boutiba-Ben Boubaker I, Slim A, Dubois V. High Prevalence of Gut Microbiota Colonization with Broad-Spectrum Cephalosporin Resistant Enterobacteriaceae in a Tunisian Intensive Care Unit. Front Microbiol. 2016 7, 1859. PubMed PMID:27965626

Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM. Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis. PLoS One. 2016 11, e0168074. PubMed PMID:27936225

Dauchy FA, Bonhivers M, Landrein N, Dacheux D, Courtois P, Lauruol F, Daulouède S, Vincendeau P, Robinson DR. Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. PLoS Negl Trop Dis. 2016 10, e0005125. PubMed PMID:27855164

Quemener C, Baud J, Boyé K, Dubrac A, Billottet C, Soulet F, Darlot F, Dumartin L, Sire M, Grepin R, Daubon T, Rayne F, Wodrich H, Couvelard A, Pineau R, Schilling M, Castronovo V, Sue SC, Clarke K, Lomri A, Khatib AM, Hagedorn M, Prats H, Bikfalvi A. Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer. Cancer Res. 2016 76, 6507-6519. PubMed PMID:27634764

Komatsu T, Nagata K, Wodrich H. The Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes. Viruses. 2016 8, . PubMed PMID:27782081

Komatsu T, Robinson DR, Hisaoka M, Ueshima S, Okuwaki M, Nagata K, Wodrich H. Tracking adenovirus genomes identifies morphologically distinct late DNA replication compartments. Traffic. 2016 17, 1168-1180. PubMed PMID:27492875

Austin S, Taouji S, Chevet E, Wodrich H, Rayne F. Using AlphaScreen(®) to Identify Small-Molecule Inhibitors Targeting a Conserved Host-Pathogen Interaction. Methods Mol Biol. 2016 1449, 453-67. PubMed PMID:27613056

Pasi M, Mornico D, Volant S, Juchet A, Batisse J, Bouchier C, Parissi V, Ruff M, Lavery R, Lavigne M. DNA minicircles clarify the specific role of DNA structure on retroviral integration. Nucleic Acids Res. 2016 44, 7830-47. PubMed PMID:27439712

Métifiot M, Johnson BC, Kiselev E, Marler L, Zhao XZ, Burke TR Jr, Marchand C, Hughes SH, Pommier Y. Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site. Nucleic Acids Res. 2016 44, 6896-906. PubMed PMID:27369381

Jayol A, Dubois V, Poirel L, Nordmann P. Rapid Detection of Polymyxin-Resistant Enterobacteriaceae from Blood Cultures. J Clin Microbiol. 2016 54, 2273-7. PubMed PMID:27307457

Bougnoux ME, Dannaoui E, Accoceberry I, Angoulvant A, Bailly E, Botterel F, Chevrier S, Chouaki T, Cornet M, Dalle F, Datry A, Dupuis A, Fekkar A, Gangneux JP, Guitard J, Hennequin C, Le Govic Y, Le Pape P, Maubon D, Ranque S, Sautour M, Sendid B, Chandenier J. Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin. Antimicrob Agents Chemother. 2016 60, 5088-91. PubMed PMID:27297480

Garrigue I, Moulinas R, Recordon-Pinson P, Delacour ML, Essig M, Kaminski H, Rerolle JP, Merville P, Fleury H, Alain S. Contribution of next generation sequencing to early detection of cytomegalovirus UL97 emerging mutants and viral subpopulations analysis in kidney transplant recipients. J Clin Virol. 2016 80, 74-81. PubMed PMID:27214758

Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepción JL, Hashimoto T, Embley TM, Nara T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids. Proc Biol Sci. 2016 283, . PubMed PMID:27170716

Billamboz M, Suchaud V, Bailly F, Lion C, Andréola ML, Christ F, Debyser Z, Cotelle P. 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4. Eur J Med Chem. 2016 117, 256-68. PubMed PMID:27105029

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK. The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism. Proteins. 2016 84, 1075-96. PubMed PMID:27093562

Komatsu T, Will H, Nagata K, Wodrich H. Imaging analysis of nuclear antiviral factors through direct detection of incoming adenovirus genome complexes. Biochem Biophys Res Commun. 2016 473, 200-205. PubMed PMID:27012198

Escudero JA, Loot C, Parissi V, Nivina A, Bouchier C, Mazel D. Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation. Nat Commun. 2016 7, 10937. PubMed PMID:26961432

Perdomo D, Bonhivers M, Robinson DR. The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein-TbBILBO1. Cells. 2016 5, . PubMed PMID:26950156

Zhao XZ, Smith SJ, Maskell DP, Metifiot M, Pye VE, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR Jr. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. ACS Chem Biol. 2016 11, 1074-81. PubMed PMID:26808478

2015

Komatsu T, Nagata K, Wodrich H. An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies. J Virol. 2016 90, 1657-67. PubMed PMID:26608315

Sari O, Roy V, Métifiot M, Marchand C, Pommier Y, Bourg S, Bonnet P, Schinazi RF, Agrofoglio LA. Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase. Eur J Med Chem. 2015 104, 127-38. PubMed PMID:26451771

Métifiot M, Amrane S, Mergny JL, Andreola ML. Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1. Biochimie. 2015 118, 173-5. PubMed PMID:26363100

Komatsu T, Dacheux D, Kreppel F, Nagata K, Wodrich H. A Method for Visualization of Incoming Adenovirus Chromatin Complexes in Fixed and Living Cells. PLoS One. 2015 10, e0137102. PubMed PMID:26332038

Austen JM, Reid SA, Robinson DR, Friend JA, Ditcham WG, Irwin PJ, Ryan U. Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos. Parasitology. 2015 142, 1443-52. PubMed PMID:26160545

Naughtin M, Haftek-Terreau Z, Xavier J, Meyer S, Silvain M, Jaszczyszyn Y, Levy N, Miele V, Benleulmi MS, Ruff M, Parissi V, Vaillant C, Lavigne M. DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity. PLoS One. 2015 10, e0129427. PubMed PMID:26075397

Rodriguez C, Soulié C, Marcelin AG, Calvez V, Descamps D, Charpentier C, Flandre P, Recordon-Pinson P, Bellecave P, Pawlotsky JM, Masquelier B, ANRS AC11 Study Group. HIV-1 Coreceptor Usage Assessment by Ultra-Deep Pyrosequencing and Response to Maraviroc. PLoS One. 2015 10, e0127816. PubMed PMID:26068869

Thierry S, Benleulmi MS, Sinzelle L, Thierry E, Calmels C, Chaignepain S, Waffo-Teguo P, Merillon JM, Budke B, Pasquet JM, Litvak S, Ciuffi A, Sung P, Connell P, Hauber I, Hauber J, Andreola ML, Delelis O, Parissi V. Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration. Chem Biol. 2015 22, 712-23. PubMed PMID:26051216

Pescatori L, Métifiot M, Chung S, Masoaka T, Cuzzucoli Crucitti G, Messore A, Pupo G, Madia VN, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Pommier Y, Marchand C, Costi R, Di Santo R. N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase. J Med Chem. 2015 58, 4610-23. PubMed PMID:25961960

Florimond C, Sahin A, Vidilaseris K, Dong G, Landrein N, Dacheux D, Albisetti A, Byard EH, Bonhivers M, Robinson DR. BILBO1 is a scaffold protein of the flagellar pocket collar in the pathogen Trypanosoma brucei. PLoS Pathog. 2015 11, e1004654. PubMed PMID:25822645

Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 12, 24. PubMed PMID:25808736

Benleulmi MS, Matysiak J, Henriquez DR, Vaillant C, Lesbats P, Calmels C, Naughtin M, Leon O, Skalka AM, Ruff M, Lavigne M, Andreola ML, Parissi V. Intasome architecture and chromatin density modulate retroviral integration into nucleosome. Retrovirology. 2015 12, 13. PubMed PMID:25807893

Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Weidt SK, Burgess KE, Breitling R, Watson DG, Bringaud F, Barrett MP. Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathog. 2015 11, e1004689. PubMed PMID:25775470

Bringaud F, Biran M, Millerioux Y, Wargnies M, Allmann S, Mazet M. Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways. Mol Microbiol. 2015 96, 917-26. PubMed PMID:25753950

Dacheux D, Roger B, Bosc C, Landrein N, Roche E, Chansel L, Trian T, Andrieux A, Papaxanthos-Roche A, Marthan R, Robinson DR, Bonhivers M. Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures. J Cell Sci. 2015 128, 1294-307. PubMed PMID:25673876

Cuzzucoli Crucitti G, Métifiot M, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Esposito F, Corona A, Cadeddu M, Marchand C, Pommier Y, Tramontano E, Costi R, Di Santo R. Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain. J Med Chem. 2015 58, 1915-28. PubMed PMID:25629256

Martinez R, Schellenberger P, Vasishtan D, Aknin C, Austin S, Dacheux D, Rayne F, Siebert A, Ruzsics Z, Gruenewald K, Wodrich H. The amphipathic helix of adenovirus capsid protein VI contributes to penton release and postentry sorting. J Virol. 2015 89, 2121-35. PubMed PMID:25473051

Yassine H, Bientz L, Cros J, Goret J, Bébéar C, Quentin C, Arpin C. Experimental evidence for IS1294b-mediated transposition of the blaCMY-2 cephalosporinase gene in Enterobacteriaceae. J Antimicrob Chemother. 2015 70, 697-700. PubMed PMID:25428924

Cassany A, Ragues J, Guan T, Bégu D, Wodrich H, Kann M, Nemerow GR, Gerace L. Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214. J Virol. 2015 89, 1719-30. PubMed PMID:25410864

Bringaud F, Rogers M, Ghedin E. Identification and analysis of ingi-related retroposons in the trypanosomatid genomes. Methods Mol Biol. 2015 1201, 109-22. PubMed PMID:25388110

2014

Allmann S, Mazet M, Ziebart N, Bouyssou G, Fouillen L, Dupuy JW, Bonneu M, Moreau P, Bringaud F, Boshart M. Triacylglycerol Storage in Lipid Droplets in Procyclic Trypanosoma brucei. PLoS One. 2014 9, e114628. PubMed PMID:25493940

Gabriel F, Accoceberry I, Bessoule JJ, Salin B, Lucas-Guérin M, Manon S, Dementhon K, Noël T. A Fox2-dependent fatty acid ß-oxidation pathway coexists both in peroxisomes and mitochondria of the ascomycete yeast Candida lusitaniae. PLoS One. 2014 9, e114531. PubMed PMID:25486052

Métifiot M, Amrane S, Litvak S, Andreola ML. G-quadruplexes in viruses: function and potential therapeutic applications. Nucleic Acids Res. 2014 42, 12352-66. PubMed PMID:25332402

Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW. Nuclear herpesvirus capsid motility is not dependent on F-actin. mBio. 2014 5, e01909-14. PubMed PMID:25293761

Korf K, Wodrich H, Haschke A, Ocampo C, Harder L, Gieseke F, Pollmann A, Dierck K, Prall S, Staege H, Ma H, Horstmann MA, Evans RM, Sternsdorf T. The PML domain of PML-RARα blocks senescence to promote leukemia. Proc Natl Acad Sci U S A. 2014 111, 12133-8. PubMed PMID:25092303

Papuchon J, Pinson P, Guidicelli GL, Bellecave P, Thomas R, LeBlanc R, Reigadas S, Taupin JL, Baril JG, Routy JP, Wainberg M, Fleury H, Provir/Latitude 45 study group. Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study. PLoS One. 2014 9, e100452. PubMed PMID:24964202

Couzigou C, Gabriel F, Biteau N, Fitton-Ouhabi V, Noël T, Accoceberry I. Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia. Med Mycol Case Rep. 2014 5, 12-5. PubMed PMID:24936404

Bellecave P, Malato L, Calmels C, Reigadas S, Parissi V, Andreola ML, Fleury H. In vitro analysis of the susceptibility of HIV-1 subtype A and CRF01_AE integrases to raltegravir. Int J Antimicrob Agents. 2014 44, 168-72. PubMed PMID:24935032

Zhao XZ, Smith SJ, Métifiot M, Marchand C, Boyer PL, Pommier Y, Hughes SH, Burke TR Jr. 4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1. J Med Chem. 2014 57, 5190-202. PubMed PMID:24901667

Gabriel F, Sabra A, El-Kirat-Chatel S, Pujol S, Fitton-Ouhabi V, Brèthes D, Dementhon K, Accoceberry I, Noël T. Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole. Antimicrob Agents Chemother. 2014 58, 4476-85. PubMed PMID:24867971

Deramchia K, Morand P, Biran M, Millerioux Y, Mazet M, Wargnies M, Franconi JM, Bringaud F. Contribution of pyruvate phosphate dikinase in the maintenance of the glycosomal ATP/ADP balance in the Trypanosoma brucei procyclic form. J Biol Chem. 2014 289, 17365-78. PubMed PMID:24794874

Suchaud V, Bailly F, Lion C, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. J Med Chem. 2014 57, 4640-60. PubMed PMID:24793360

Simen BB, Braverman MS, Abbate I, Aerssens J, Bidet Y, Bouchez O, Gabriel C, Izopet J, Kessler HH, Stelzl E, Di Giallonardo F, Schlapbach R, Radonic A, Paredes R, Recordon-Pinson P, Sakwa J, St John EP, Schmitz-Agheguian GG, Metzner KJ, Däumer MP, 454 HIV Alphastudy Group. An international multicenter study on HIV-1 drug resistance testing by 454 ultra-deep pyrosequencing. J Virol Methods. 2014 204, 31-7. PubMed PMID:24731928

Sana F, Mabrouka S, Claudine Q, Faouzi SA, Ilhem BB, Véronique D. Prevalence and characterization of uropathogenic Escherichia coli harboring plasmid-mediated quinolone resistance in a Tunisian university hospital. Diagn Microbiol Infect Dis. 2014 79, 247-51. PubMed PMID:24731835

Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia VN, Pupo G, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Corona A, Pommier Y, Marchand C, Di Santo R. Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase. J Med Chem. 2014 57, 3223-34. PubMed PMID:24684270

Cougnoux A, Dalmasso G, Martinez R, Buc E, Delmas J, Gibold L, Sauvanet P, Darcha C, Déchelotte P, Bonnet M, Pezet D, Wodrich H, Darfeuille-Michaud A, Bonnet R. Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype. Gut. 2014 63, 1932-42. PubMed PMID:24658599

Amrane S, Kerkour A, Bedrat A, Vialet B, Andreola ML, Mergny JL. Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development. J Am Chem Soc. 2014 136, 5249-52. PubMed PMID:24649937

Porcel BM, Denoeud F, Opperdoes F, Noel B, Madoui MA, Hammarton TC, Field MC, Da Silva C, Couloux A, Poulain J, Katinka M, Jabbari K, Aury JM, Campbell DA, Cintron R, Dickens NJ, Docampo R, Sturm NR, Koumandou VL, Fabre S, Flegontov P, Lukeš J, Michaeli S, Mottram JC, Szöőr B, Zilberstein D, Bringaud F, Wincker P, Dollet M. The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genet. 2014 10, e1004007. PubMed PMID:24516393

Vandenhende MA, Bellecave P, Recordon-Pinson P, Reigadas S, Bidet Y, Bruyand M, Bonnet F, Lazaro E, Neau D, Fleury H, Dabis F, Morlat P, Masquelier B. Prevalence and evolution of low frequency HIV drug resistance mutations detected by ultra deep sequencing in patients experiencing first line antiretroviral therapy failure. PLoS One. 2014 9, e86771. PubMed PMID:24475178

Zhao XZ, Smith SJ, Métifiot M, Johnson BC, Marchand C, Pommier Y, Hughes SH, Burke TR Jr. Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants. J Med Chem. 2014 57, 1573-82. PubMed PMID:24471816

2013

Billamboz M, Suchaud V, Bailly F, Lion C, Demeulemeester J, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. ACS Med Chem Lett. 2013 4, 606-11. PubMed PMID:24900718

Mazet M, Morand P, Biran M, Bouyssou G, Courtois P, Daulouède S, Millerioux Y, Franconi JM, Vincendeau P, Moreau P, Bringaud F. Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability. PLoS Negl Trop Dis. 2013 7, e2587. PubMed PMID:24367711

Pflieger A, Waffo Teguo P, Papastamoulis Y, Chaignepain S, Subra F, Munir S, Delelis O, Lesbats P, Calmels C, Andreola ML, Merillon JM, Auge-Gouillou C, Parissi V. Natural stilbenoids isolated from grapevine exhibiting inhibitory effects against HIV-1 integrase and eukaryote MOS1 transposase in vitro activities. PLoS One. 2013 8, e81184. PubMed PMID:24312275

Porwal M, Cohen S, Snoussi K, Popa-Wagner R, Anderson F, Dugot-Senant N, Wodrich H, Dinsart C, Kleinschmidt JA, Panté N, Kann M. Parvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosis. PLoS Pathog. 2013 9, e1003671. PubMed PMID:24204256

Škodová I, Verner Z, Bringaud F, Fabian P, Lukeš J, Horváth A. Characterization of two mitochondrial flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenases in Trypanosoma brucei. Eukaryot Cell. 2013 12, 1664-73. PubMed PMID:24142106

Costi R, Métifiot M, Esposito F, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Zinzula L, Novellino E, Pommier Y, Tramontano E, Marchand C, Di Santo R. 6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach. J Med Chem. 2013 56, 8588-98. PubMed PMID:24124919

Martinez R, Burrage AM, Wiethoff CM, Wodrich H. High temporal resolution imaging reveals endosomal membrane penetration and escape of adenoviruses in real time. Methods Mol Biol. 2013 1064, 211-26. PubMed PMID:23996260

Bosse JB, Ragues J, Wodrich H. Fast generation of stable cell lines expressing fluorescent marker molecules to study pathogen induced processes. Methods Mol Biol. 2013 1064, 153-69. PubMed PMID:23996256

Millerioux Y, Ebikeme C, Biran M, Morand P, Bouyssou G, Vincent IM, Mazet M, Riviere L, Franconi JM, Burchmore RJ, Moreau P, Barrett MP, Bringaud F. The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Mol Microbiol. 2013 90, 114-29. PubMed PMID:23899193

Nomura W, Aikawa H, Ohashi N, Urano E, Métifiot M, Fujino M, Maddali K, Ozaki T, Nozue A, Narumi T, Hashimoto C, Tanaka T, Pommier Y, Yamamoto N, Komano JA, Murakami T, Tamamura H. Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products. ACS Chem Biol. 2013 8, 2235-44. PubMed PMID:23898787

Métifiot M, Marchand C, Pommier Y. HIV integrase inhibitors: 20-year landmark and challenges. Adv Pharmacol. 2013 67, 75-105. PubMed PMID:23885999

Papuchon J, Pinson P, Lazaro E, Reigadas S, Guidicelli G, Taupin JL, Neau D, Fleury H, Provir/Latitude 45 project. Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine. PLoS One. 2013 8, e69029. PubMed PMID:23874854

Schreiner S, Wodrich H. Virion factors that target Daxx to overcome intrinsic immunity. J Virol. 2013 87, 10412-22. PubMed PMID:23864634

Capewell P, Monk S, Ivens A, Macgregor P, Fenn K, Walrad P, Bringaud F, Smith TK, Matthews KR. Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host. PLoS One. 2013 8, e67069. PubMed PMID:23840587

Houard J, Aumelas A, Noël T, Pages S, Givaudan A, Fitton-Ouhabi V, Villain-Guillot P, Gualtieri M. Cabanillasin, a new antifungal metabolite, produced by entomopathogenic Xenorhabdus cabanillasii JM26. J Antibiot (Tokyo). 2013 66, 617-20. PubMed PMID:23756685

Allmann S, Morand P, Ebikeme C, Gales L, Biran M, Hubert J, Brennand A, Mazet M, Franconi JM, Michels PA, Portais JC, Boshart M, Bringaud F. Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. J Biol Chem. 2013 288, 18494-505. PubMed PMID:23665470

Charbonneau V, Garrigue I, Jaquet A, Horo A, Minga A, Recordon-Pinson P, Dabis F, Fleury H. Dried cervical spots for human papillomaviruses identification. J Med Virol. 2013 85, 1222-8. PubMed PMID:23595602

Johnson BC, Métifiot M, Ferris A, Pommier Y, Hughes SH. A homology model of HIV-1 integrase and analysis of mutations designed to test the model. J Mol Biol. 2013 425, 2133-46. PubMed PMID:23542006

Cosnefroy O, Jaspart A, Calmels C, Parissi V, Fleury H, Ventura M, Reigadas S, Andréola ML. Activation of GCN2 upon HIV-1 infection and inhibition of translation. Cell Mol Life Sci. 2013 70, 2411-21. PubMed PMID:23417324

Recordon-Pinson P, Raymond S, Bellecave P, Marcelin AG, Soulie C, Descamps D, Calvez V, Harrigan PR, Fleury H, Izopet J, Masquelier B, S AC11 Resistance Study Group. HIV-1 dynamics and coreceptor usage in Maraviroc-treated patients with ongoing replication. Antimicrob Agents Chemother. 2013 57, 930-5. PubMed PMID:23208718

2012

Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. 6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors. Bioorg Med Chem Lett. 2012 22, 7309-13. PubMed PMID:23149229

Ghozlane A, Bringaud F, Soueidan H, Dutour I, Jourdan F, Thébault P. Flux Analysis of the Trypanosoma brucei Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach. Adv Bioinformatics. 2012 2012, 159423. PubMed PMID:23097667

Peña-Diaz P, Pelosi L, Ebikeme C, Colasante C, Gao F, Bringaud F, Voncken F. Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei. J Biol Chem. 2012 287, 41861-74. PubMed PMID:23074217

Godel C, Kumar S, Koutsovoulos G, Ludin P, Nilsson D, Comandatore F, Wrobel N, Thompson M, Schmid CD, Goto S, Bringaud F, Wolstenholme A, Bandi C, Epe C, Kaminsky R, Blaxter M, Mäser P. The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. FASEB J. 2012 26, 4650-61. PubMed PMID:22889830

Maier O, Marvin SA, Wodrich H, Campbell EM, Wiethoff CM. Spatiotemporal dynamics of adenovirus membrane rupture and endosomal escape. J Virol. 2012 86, 10821-8. PubMed PMID:22855481

Cornillot E, Hadj-Kaddour K, Dassouli A, Noel B, Ranwez V, Vacherie B, Augagneur Y, Brès V, Duclos A, Randazzo S, Carcy B, Debierre-Grockiego F, Delbecq S, Moubri-Ménage K, Shams-Eldin H, Usmani-Brown S, Bringaud F, Wincker P, Vivarès CP, Schwarz RT, Schetters TP, Krause PJ, Gorenflot A, Berry V, Barbe V, Ben Mamoun C. Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti. Nucleic Acids Res. 2012 40, 9102-14. PubMed PMID:22833609

Andréola ML, Litvak S. Yeast and the AIDS virus: the odd couple. J Biomed Biotechnol. 2012 2012, 549020. PubMed PMID:22778552

Cahoreau E, Peyriga L, Hubert J, Bringaud F, Massou S, Portais JC. Isotopic profiling of ¹³C-labeled biological samples by two-dimensional heteronuclear J-resolved nuclear magnetic resonance spectroscopy. Anal Biochem. 2012 427, 158-63. PubMed PMID:22658961

Berciaud S, Rayne F, Kassab S, Jubert C, Faure-Della Corte M, Salin F, Wodrich H, Lafon ME, Typadeno Study Members. Adenovirus infections in Bordeaux University Hospital 2008-2010: clinical and virological features. J Clin Virol. 2012 54, 302-7. PubMed PMID:22608365

Dementhon K, El-Kirat-Chatel S, Noël T. Development of an in vitro model for the multi-parametric quantification of the cellular interactions between Candida yeasts and phagocytes. PLoS One. 2012 7, e32621. PubMed PMID:22479332

Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, Wargnies M, Ebikeme C, Deramchia K, Gales L, Portais JC, Boshart M, Franconi JM, Bringaud F. ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma. J Biol Chem. 2012 287, 17186-97. PubMed PMID:22474284

Arpin C, Noury P, Boraud D, Coulange L, Manetti A, André C, M'Zali F, Quentin C. NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel. Antimicrob Agents Chemother. 2012 56, 3432-4. PubMed PMID:22450982

Odintsova ES, Baranova SV, Dmitrenok PS, Calmels C, Parissi V, Andreola ML, Buneva VN, Nevinsky GA. Anti-integrase abzymes from the sera of HIV-infected patients specifically hydrolyze integrase but nonspecifically cleave short oligopeptides. J Mol Recognit. 2012 25, 193-207. PubMed PMID:22434709

Schreiner S, Martinez R, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Marcinowski L, Ruzsics Z, Dobner T, Wodrich H. Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. PLoS Pathog. 2012 8, e1002549. PubMed PMID:22427750

Dacheux D, Landrein N, Thonnus M, Gilbert G, Sahin A, Wodrich H, Robinson DR, Bonhivers M. A MAP6-related protein is present in protozoa and is involved in flagellum motility. PLoS One. 2012 7, e31344. PubMed PMID:22355359

May SF, Peacock L, Almeida Costa CI, Gibson WC, Tetley L, Robinson DR, Hammarton TC. The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement. Mol Microbiol. 2012 84, 77-92. PubMed PMID:22329999

Bringaud F, Barrett MP, Zilberstein D. Multiple roles of proline transport and metabolism in trypanosomatids. Front Biosci (Landmark Ed). 2012 17, 349-74. PubMed PMID:22201748

Gualdrón-López M, Brennand A, Hannaert V, Quiñones W, Cáceres AJ, Bringaud F, Concepción JL, Michels PA. When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle. Int J Parasitol. 2012 42, 1-20. PubMed PMID:22142562

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors. Chem Biol Drug Des. 2012 79, 157-65. PubMed PMID:22107736

Johnson BC, Métifiot M, Pommier Y, Hughes SH. Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity. Antimicrob Agents Chemother. 2012 56, 411-9. PubMed PMID:22037850

2011

Reyes N, Oh S, Boudker O. Binding thermodynamics of a glutamate transporter homolog. Nat Struct Mol Biol. 2013 20, 634-40. PubMed PMID:23563139

Odintsova ES, Baranova SV, Buneva VN, Calmels C, Parissi V, Andreola ML, Zakharova OD, Nevinsky GA. Catalytic antibodies from HIV-infected patients specifically hydrolyzing viral integrase suppress the enzyme catalytic activities. J Mol Recognit. 24, 1067-76. PubMed PMID:22038813

Reyes N, Tavoulari S. To be, or not to be two sites: that is the question about LeuT substrate binding. J Gen Physiol. 2011 138, 467-71. PubMed PMID:21911482

Mazet M, Harijan RK, Kiema TR, Haapalainen AM, Morand P, Morales J, Bringaud F, Wierenga RK, Michels PA. The characterization and evolutionary relationships of a trypanosomal thiolase. Int J Parasitol. 2011 41, 1273-83. PubMed PMID:21907205

Métifiot M, Johnson B, Smith S, Zhao XZ, Marchand C, Burke T, Hughes S, Pommier Y. MK-0536 inhibits HIV-1 integrases resistant to raltegravir. Antimicrob Agents Chemother. 2011 55, 5127-33. PubMed PMID:21876054

Odintsova ES, Baranova SV, Dmitrenok PS, Rasskazov VA, Calmels C, Parissi V, Andreola ML, Buneva VN, Zakharova OD, Nevinsky GA. Antibodies to HIV integrase catalyze site-specific degradation of their antigen. Int Immunol. 2011 23, 601-12. PubMed PMID:21862667

Hare S, Smith SJ, Métifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov P. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 80, 565-72. PubMed PMID:21719464

Bringaud F, Berriman M, Hertz-Fowler C. TSIDER1, a short and non-autonomous Salivarian trypanosome-specific retroposon related to the ingi6 subclade. Mol Biochem Parasitol. 2011 179, 30-6. PubMed PMID:21664383

Reigadas S, Masquelier B, Calmels C, Laguerre M, Lazaro E, Vandenhende M, Neau D, Fleury H, Andréola ML. Structure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97A. Antimicrob Agents Chemother. 2011 55, 3187-94. PubMed PMID:21576445

Stoffel SA, Alibu VP, Hubert J, Ebikeme C, Portais JC, Bringaud F, Schweingruber ME, Barrett MP. Transketolase in Trypanosoma brucei. Mol Biochem Parasitol. 2011 179, 1-7. PubMed PMID:21570429

Boyer A, Amadeo B, Vargas F, Yu M, Maurice-Tison S, Dubois V, Bébéar C, Rogues AM, Gruson D. Severe community-acquired Enterobacter pneumonia: a plea for greater awareness of the concept of health-care-associated pneumonia. BMC Infect Dis. 2011 11, 120. PubMed PMID:21569334

Faure-Perraud A, Métifiot M, Reigadas S, Recordon-Pinson P, Parissi V, Ventura M, Andréola ML. The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration. Antivir Ther. 2011 16, 383-94. PubMed PMID:21555821

Métifiot M, Vandegraaff N, Maddali K, Naumova A, Zhang X, Rhodes D, Marchand C, Pommier Y. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. AIDS. 2011 25, 1175-8. PubMed PMID:21505303

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors. Bioorg Med Chem Lett. 2011 21, 2986-90. PubMed PMID:21493066

Millerioux Y, Clastre M, Simkin AJ, Courdavault V, Marais E, Sibirny AA, Noël T, Crèche J, Giglioli-Guivarc'h N, Papon N. Drug-resistant cassettes for the efficient transformation of Candida guilliermondii wild-type strains. FEMS Yeast Res. 2011 11, 457-63. PubMed PMID:21489135

El-Kirat-Chatel S, Dementhon K, Noël T. A two-step cloning-free PCR-based method for the deletion of genes in the opportunistic pathogenic yeast Candida lusitaniae. Yeast. 2011 28, 321-30. PubMed PMID:21456057

Tang J, Maddali K, Metifiot M, Sham YY, Vince R, Pommier Y, Wang Z. 3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase. J Med Chem. 2011 54, 2282-92. PubMed PMID:21381765

Billamboz M, Bailly F, Lion C, Touati N, Vezin H, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function. J Med Chem. 2011 54, 1812-24. PubMed PMID:21366258

Lesbats P, Botbol Y, Chevereau G, Vaillant C, Calmels C, Arneodo A, Andreola ML, Lavigne M, Parissi V. Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes. PLoS Pathog. 2011 7, e1001280. PubMed PMID:21347347

Billamboz M, Bailly F, Lion C, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, De Luca L, Chimirri A, Cotelle P. 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. Eur J Med Chem. 2011 46, 535-46. PubMed PMID:21185110

2010

Métifiot M, Marchand C, Maddali K, Pommier Y. Resistance to integrase inhibitors. Viruses. 2010 2, 1347-66. PubMed PMID:20706558

Ebikeme C, Hubert J, Biran M, Gouspillou G, Morand P, Plazolles N, Guegan F, Diolez P, Franconi JM, Portais JC, Bringaud F. Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism. J Biol Chem. 2010 285, 32312-24. PubMed PMID:20702405

Ness F, Prouzet-Mauleon V, Vieillemard A, Lefebvre F, Noël T, Crouzet M, Doignon F, Thoraval D. The Candida albicans Rgd1 is a RhoGAP protein involved in the control of filamentous growth. Fungal Genet Biol. 2010 47, 1001-11. PubMed PMID:20637818

Baranova SV, Buneva VN, Kharitonova MA, Sizyakina LP, Calmels C, Andreola ML, Parissi V, Zakharova OD, Nevinsky GA. HIV-1 integrase-hydrolyzing IgM antibodies from sera of HIV-infected patients. Int Immunol. 2010 22, 671-80. PubMed PMID:20507874

Dubois V, De Barbeyrac B, Rogues AM, Arpin C, Coulange L, Andre C, M'zali F, Megraud F, Quentin C. CTX-M-producing Escherichia coli in a maternity ward: a likely community importation and evidence of mother-to-neonate transmission. J Antimicrob Chemother. 2010 65, 1368-71. PubMed PMID:20466850

Reigadas S, Anies G, Masquelier B, Calmels C, Stuyver LJ, Parissi V, Fleury H, Andreola ML. The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. PLoS One. 2010 5, e10311. PubMed PMID:20436677

Maier O, Galan DL, Wodrich H, Wiethoff CM. An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature. Virology. 2010 402, 11-9. PubMed PMID:20409568

Deshpande A, Jeannot AC, Schrive MH, Wittkop L, Pinson P, Fleury HJ. Analysis of RT sequences of subtype C HIV-type 1 isolates from indian patients at failure of a first-line treatment according to clinical and/or immunological WHO guidelines. AIDS Res Hum Retroviruses. 2010 26, 343-50. PubMed PMID:20334569

Métifiot M, Maddali K, Naumova A, Zhang X, Marchand C, Pommier Y. Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir. Biochemistry. 2010 49, 3715-22. PubMed PMID:20334344

Wodrich H, Henaff D, Jammart B, Segura-Morales C, Seelmeir S, Coux O, Ruzsics Z, Wiethoff CM, Kremer EJ. A capsid-encoded PPxY-motif facilitates adenovirus entry. PLoS Pathog. 2010 6, e1000808. PubMed PMID:20333243

Manganaro L, Lusic M, Gutierrez MI, Cereseto A, Del Sal G, Giacca M. Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes. Nat Med. 2010 16, 329-33. PubMed PMID:20173753

Ba BB, Arpin C, Bikie Bi Nso B, Dubois V, Saux MC, Quentin C. Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. Antimicrob Agents Chemother. 2010 54, 1443-52. PubMed PMID:20100878

Reigadas S, Andréola ML, Wittkop L, Cosnefroy O, Anies G, Recordon-Pinson P, Thiébaut R, Masquelier B, Fleury H. Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells. J Antimicrob Chemother. 2010 65, 434-7. PubMed PMID:20051476

Chapeland-Leclerc F, Hennequin C, Papon N, Noël T, Girard A, Socié G, Ribaud P, Lacroix C. Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. Antimicrob Agents Chemother. 2010 54, 1360-2. PubMed PMID:20038613

Bringaud F, Ebikeme C, Boshart M. Acetate and succinate production in amoebae, helminths, diplomonads, trichomonads and trypanosomatids: common and diverse metabolic strategies used by parasitic lower eukaryotes. Parasitology. 2010 137, 1315-31. PubMed PMID:20028611

2009

Reyes N, Ginter C, Boudker O. Transport mechanism of a bacterial homologue of glutamate transporters. Nature. 2009 462, 880-5. PubMed PMID:19924125

Spitznagel D, Ebikeme C, Biran M, Nic a' Bháird N, Bringaud F, Henehan GT, Nolan DP. Alanine aminotransferase of Trypanosoma brucei--a key role in proline metabolism in procyclic life forms. FEBS J. 2009 276, 7187-99. PubMed PMID:19895576

Takeuchi A, Reyes N, Artigas P, Gadsby DC. Visualizing the mapped ion pathway through the Na,K-ATPase pump. Channels (Austin). 2009 3, 383-6. PubMed PMID:19806033

Marchand C, Maddali K, Métifiot M, Pommier Y. HIV-1 IN inhibitors: 2010 update and perspectives. Curr Top Med Chem. 2009 9, 1016-37. PubMed PMID:19747122

Giroud C, Ottones F, Coustou V, Dacheux D, Biteau N, Miezan B, Van Reet N, Carrington M, Doua F, Baltz T. Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism. PLoS Negl Trop Dis. 2009 3, e509. PubMed PMID:19721701

Bringaud F, Berriman M, Hertz-Fowler C. Trypanosomatid genomes contain several subfamilies of ingi-related retroposons. Eukaryot Cell. 2009 8, 1532-42. PubMed PMID:19666780

Rivière L, Moreau P, Allmann S, Hahn M, Biran M, Plazolles N, Franconi JM, Boshart M, Bringaud F. Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes. Proc Natl Acad Sci U S A. 2009 106, 12694-9. PubMed PMID:19625628

Ben-Ami R, Rodríguez-Baño J, Arslan H, Pitout JD, Quentin C, Calbo ES, Azap OK, Arpin C, Pascual A, Livermore DM, Garau J, Carmeli Y. A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients. Clin Infect Dis. 2009 49, 682-90. PubMed PMID:19622043

Gordien JB, Pigneux A, Vigouroux S, Tabrizi R, Accoceberry I, Bernadou JM, Rouault A, Saux MC, Breilh D. Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection. J Pharm Biomed Anal. 2009 50, 932-8. PubMed PMID:19608374

Andréola ML. Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase. Curr Pharm Des. 2009 15, 2508-19. PubMed PMID:19601847

Baranova SV, Buneva VN, Kharitonova MA, Sizyakina LP, Calmels C, Andreola ML, Parissi V, Nevinsky GA. HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients. Biochimie. 2009 91, 1081-6. PubMed PMID:19580842

Smith M, Bringaud F, Papadopoulou B. Organization and evolution of two SIDER retroposon subfamilies and their impact on the Leishmania genome. BMC Genomics. 2009 10, 240. PubMed PMID:19463167

Florent M, Noël T, Ruprich-Robert G, Da Silva B, Fitton-Ouhabi V, Chastin C, Papon N, Chapeland-Leclerc F. Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. Antimicrob Agents Chemother. 2009 53, 2982-90. PubMed PMID:19414575

Dubois V, Debreyer C, Quentin C, Parissi V. In vitro recombination catalyzed by bacterial class 1 integron integrase IntI1 involves cooperative binding and specific oligomeric intermediates. PLoS One. 2009 4, e5228. PubMed PMID:19381299

Desfarges S, Salin B, Calmels C, Andreola ML, Parissi V, Fournier M. HIV-1 integrase trafficking in S. cerevisiae: a useful model to dissect the microtubule network involvement of viral protein nuclear import. Yeast. 2009 26, 39-54. PubMed PMID:19180639

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ. The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009 5, e1000277. PubMed PMID:19119424

Reboutier D, Piednoël M, Boisnard S, Conti A, Chevalier V, Florent M, Gibot-Leclerc S, Da Silva B, Chastin C, Fallague K, Favel A, Noël T, Ruprich-Robert G, Chapeland-Leclerc F, Papon N. Combination of different molecular mechanisms leading to fluconazole resistance in a Candida lusitaniae clinical isolate. Diagn Microbiol Infect Dis. 2009 63, 188-93. PubMed PMID:19070454

Dolan J, Chen A, Weber IT, Harrison RW, Leis J. Defining the DNA substrate binding sites on HIV-1 integrase. J Mol Biol. 2009 385, 568-79. PubMed PMID:19014951

Gadsby DC, Takeuchi A, Artigas P, Reyes N. Review. Peering into an ATPase ion pump with single-channel recordings. Philos Trans R Soc Lond B Biol Sci. 2009 364, 229-38. PubMed PMID:18986966

Oyola SO, Bringaud F, Melville SE. A kinetoplastid BRCA2 interacts with DNA replication protein CDC45. Int J Parasitol. 2009 39, 59-69. PubMed PMID:18723021

2008

Billamboz M, Bailly F, Barreca ML, De Luca L, Mouscadet JF, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, Cotelle P. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem. 2008 51, 7717-30. PubMed PMID:19053754

Lesbats P, Métifiot M, Calmels C, Baranova S, Nevinsky G, Andreola ML, Parissi V. In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state. Nucleic Acids Res. 2008 36, 7043-58. PubMed PMID:18987001

Absalon S, Blisnick T, Bonhivers M, Kohl L, Cayet N, Toutirais G, Buisson J, Robinson D, Bastin P. Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei. J Cell Sci. 2008 121, 3704-16. PubMed PMID:18940910

Takeuchi A, Reyes N, Artigas P, Gadsby DC. The ion pathway through the opened Na(+),K(+)-ATPase pump. Nature. 2008 456, 413-6. PubMed PMID:18849964

Dubois V, Poirel L, Demarthe F, Arpin C, Coulange L, Minarini LA, Bezian MC, Nordmann P, Quentin C. Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother. 2008 52, 3792-4. PubMed PMID:18663019

Bonhivers M, Landrein N, Decossas M, Robinson DR. A monoclonal antibody marker for the exclusion-zone filaments of Trypanosoma brucei. Parasit Vectors. 2008 1, 21. PubMed PMID:18616805

Van de Velde S, Nguyen HA, Van Bambeke F, Tulkens PM, Grellet J, Dubois V, Quentin C, Saux MC. Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes. J Antimicrob Chemother. 2008 62, 518-21. PubMed PMID:18544595

Dubois V, Arpin C, Dupart V, Scavelli A, Coulange L, André C, Fischer I, Grobost F, Brochet JP, Lagrange I, Dutilh B, Jullin J, Noury P, Larribet G, Quentin C. Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres). J Antimicrob Chemother. 2008 62, 316-23. PubMed PMID:18467306

Bringaud F, Ghedin E, El-Sayed NM, Papadopoulou B. Role of transposable elements in trypanosomatids. Microbes Infect. 2008 10, 575-81. PubMed PMID:18467144

Bonhivers M, Nowacki S, Landrein N, Robinson DR. Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated. PLoS Biol. 2008 6, e105. PubMed PMID:18462016

Coustou V, Biran M, Breton M, Guegan F, Rivière L, Plazolles N, Nolan D, Barrett MP, Franconi JM, Bringaud F. Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. J Biol Chem. 2008 283, 16342-54. PubMed PMID:18430732

Ebikeme CE, Peacock L, Coustou V, Riviere L, Bringaud F, Gibson WC, Barrett MP. N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology. 2008 135, 585-94. PubMed PMID:18371239

Bellecave P, Cazenave C, Rumi J, Staedel C, Cosnefroy O, Andreola ML, Ventura M, Tarrago-Litvak L, Astier-Gin T. Inhibition of hepatitis C virus (HCV) RNA polymerase by DNA aptamers: mechanism of inhibition of in vitro RNA synthesis and effect on HCV-infected cells. Antimicrob Agents Chemother. 2008 52, 2097-110. PubMed PMID:18347106

Sahin A, Espiau B, Tetaud E, Cuvillier A, Lartigue L, Ambit A, Robinson DR, Merlin G. The leishmania ARL-1 and Golgi traffic. PLoS One. 2008 3, e1620. PubMed PMID:18286177

Hernould M, Gagné S, Fournier M, Quentin C, Arpin C. Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. Antimicrob Agents Chemother. 2008 52, 1559-63. PubMed PMID:18268083

2007

Dubois V, Debreyer C, Litvak S, Quentin C, Parissi V. A new in vitro strand transfer assay for monitoring bacterial class 1 integron recombinase IntI1 activity. PLoS One. 2007 2, e1315. PubMed PMID:18091989

Ivanova G, Arzumanov A, Gait MJ, Reigadas S, Toulmé JJ, Andreola ML, Ittig D, Leumann C. Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression. Nucleosides Nucleotides Nucleic Acids. 2007 26, 747-50. PubMed PMID:18066894

Vidaillac C, Guillon J, Moreau S, Arpin C, Lagardère A, Larrouture S, Dallemagne P, Caignard DH, Quentin C, Jarry C. Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors. J Enzyme Inhib Med Chem. 2007 22, 620-31. PubMed PMID:18035830

Bringaud F, Müller M, Cerqueira GC, Smith M, Rochette A, El-Sayed NM, Papadopoulou B, Ghedin E. Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. PLoS Pathog. 2007 3, 1291-307. PubMed PMID:17907803

Métifiot M, Faure A, Guyonnet-Duperat V, Bellecave P, Litvak S, Ventura M, Andréola ML. Cellular uptake of ODNs in HIV-1 human-infected cells: a role for viral particles in DNA delivery?. Oligonucleotides. 2007 17, 151-65. PubMed PMID:17638520

Arpin C, Coulange L, Dubois V, André C, Fischer I, Fourmaux S, Grobost F, Jullin J, Dutilh B, Couture JF, Noury P, Lagrange I, Ducastaing A, Doermann HP, Quentin C. Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. Antimicrob Agents Chemother. 2007 51, 3440-4. PubMed PMID:17591853

Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF, Berriman M. Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet. 2007 39, 839-47. PubMed PMID:17572675

Ivanova G, Reigadas S, Ittig D, Arzumanov A, Andreola ML, Leumann C, Toulmé JJ, Gait MJ. Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity. Oligonucleotides. 2007 17, 54-65. PubMed PMID:17461763

Abdelbaqi K, Ménard A, Prouzet-Mauleon V, Bringaud F, Lehours P, Mégraud F. Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates. FEMS Immunol Med Microbiol. 2007 49, 337-45. PubMed PMID:17378897

Nguyen HA, Grellet J, Dubois V, Saux MC, Quentin C. Factors compromising the activity of moxifloxacin against intracellular Staphylococcus aureus. J Antimicrob Chemother. 2007 59, 755-8. PubMed PMID:17353222

Dubois V, Parizano MP, Arpin C, Coulange L, Bezian MC, Quentin C. High genetic stability of integrons in clinical isolates of Shigella spp. of worldwide origin. Antimicrob Agents Chemother. 2007 51, 1333-40. PubMed PMID:17242143

Vidaillac C, Guillon J, Arpin C, Forfar-Bares I, Ba BB, Grellet J, Moreau S, Caignard DH, Jarry C, Quentin C. Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Antimicrob Agents Chemother. 2007 51, 831-8. PubMed PMID:17101679

2006

Michels PA, Bringaud F, Herman M, Hannaert V. Metabolic functions of glycosomes in trypanosomatids. Biochim Biophys Acta. 2006 1763, 1463-77. PubMed PMID:17023066

Reyes N, Gadsby DC. Ion permeation through the Na+,K+-ATPase. Nature. 2006 443, 470-4. PubMed PMID:17006516

Wodrich H, Cassany A, D'Angelo MA, Guan T, Nemerow G, Gerace L. Adenovirus core protein pVII is translocated into the nucleus by multiple import receptor pathways. J Virol. 2006 80, 9608-18. PubMed PMID:16973564

Coustou V, Biran M, Besteiro S, Rivière L, Baltz T, Franconi JM, Bringaud F. Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei. J Biol Chem. 2006 281, 26832-46. PubMed PMID:16857679

Ba BB, Arpin C, Vidaillac C, Chausse A, Saux MC, Quentin C. Activity of gatifloxacin in an in vitro pharmacokinetic-pharmacodynamic model against Staphylococcus aureus strains either susceptible to ciprofloxacin or exhibiting various levels and mechanisms of ciprofloxacin resistance. Antimicrob Agents Chemother. 2006 50, 1931-6. PubMed PMID:16723548

Bringaud F, Rivière L, Coustou V. Energy metabolism of trypanosomatids: adaptation to available carbon sources. Mol Biochem Parasitol. 2006 149, 1-9. PubMed PMID:16682088

Dubois V, Arpin C, Coulange L, André C, Noury P, Quentin C. TEM-21 extended-spectrum beta-lactamase in a clinical isolate of Alcaligenes faecalis from a nursing home. J Antimicrob Chemother. 2006 57, 368-9. PubMed PMID:16344284

Espiau B, Lemercier G, Ambit A, Bringaud F, Merlin G, Baltz T, Bakalara N. A soluble pyrophosphatase, a key enzyme for polyphosphate metabolism in Leishmania. J Biol Chem. 2006 281, 1516-23. PubMed PMID:16291745

Bringaud F, Bartholomeu DC, Blandin G, Delcher A, Baltz T, El-Sayed NM, Ghedin E. The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion. Mol Biol Evol. 2006 23, 411-20. PubMed PMID:16267142

Bringaud F, Ghedin E, Blandin G, Bartholomeu DC, Caler E, Levin MJ, Baltz T, El-Sayed NM. Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements. Mol Biochem Parasitol. 2006 145, 158-70. PubMed PMID:16257065