Viruses, Retroviruses, Integration, Integrases, DNA mobility, Chromatin, DNA repair
Identify molecular exchanges between pathogenic mobile elements (viral and pseudoviral) and the host.
DNA and chromatin, or pseudocromatin, structures regulate numerous biological and pathogenic mechanisms as bacterial integrons mobilisation or retroviral integration. These processes constitute therapeutic target and attractive tools for gene transfer/therapy. Our team aims to understand these mechanisms in different models of mobile elements (viral infections, procaryotic, eukaryotic and viral integration/transposition) using complementary biophysics, biochemistry, structural/cellular biology and pharmacology approaches (Fig 1).
1- Determination of the retroviral intasome/nucleosome interfaces
2- Identification of the structural basis for viral genome anchoring to host chromatin
3- Study of the cellular responses to pathogenic genomes mobility
4- Development of new therapeutic strategies
The project X- Determination of the chemical distribution profile of human cells infected by HIV-1 using Particule Induced X-ray Emission
The project AlphaNeuroCov or COVID activities