Key words
Viruses, Retroviruses, Integration, Integrases, DNA mobility, Chromatin, DNA repair
Objectives:
Identify molecular exchanges between pathogenic mobile elements (viral and pseudoviral) and the host.
Scientific topics:
DNA and chromatin, or pseudocromatin, structures regulate numerous biological and pathogenic mechanisms as bacterial integrons mobilisation or retroviral integration. These processes constitute therapeutic target and attractive tools for gene transfer/therapy. Our team aims to understand these mechanisms in different models of mobile elements (viral infections, procaryotic, eukaryotic and viral integration/transposition) using complementary biophysics, biochemistry, structural/cellular biology and pharmacology approaches (Fig 1).
Main projects:
1- Determination of the retroviral intasome/nucleosome interfaces
2- Identification of the structural basis for viral genome anchoring to host chromatin
3- Study of the cellular responses to pathogenic genomes mobility
4- Development of new therapeutic strategies
Additional projects:
The project AlphaNeuroCov or COVID activities
Main experimental approaches
Biochemical approaches
Cellular approaches
